Herbal compounds that protect against neurodegenerative diseases

Herbal compounds from the following plant sources have been found to have neuroprotection ability in various neurological disorders (original article). 

Herbal DrugsPlant SourcesInvolved Mechanism (s)Treated Model
6-hydroxycleroda-3,13-dien-15,16-olide (PL3)Polyalthia longifolia var. pendulacytokine regulationLPS-induced model
AmpelopsinAmpelopsis grossedentatacytokine regulation, autophagy regulationStroke, brain aging
Astragaloside IVAstragalus membranaceusER stressPD
BaicaleinScutellaria baicalensis and S. laterifloraautophagy regulation, ER stressPD
BerberineCoptis chinensiscytokine regulation, autophagy regulationdepression, AD, and ALS
BreviscapineErigerin breviscapusautophagy regulationcerebral ischemic
n-butylidenephthalideAngelica sinensisautophagy regulation, neurotransmitters and synaptic functionALS, SCA3, and down syndrome model
Carnosic acidRosmarinus officinalisautophagy regulationAD and PD
ConophyllineErvatamia microphyllaautophagy regulationPD and HD
CrocinCrocus sativusER stressPD and AD
Cucurbitacin EWilbrandia ebracteataautophagy regulationPD
EriodictyolDracocephalum rupestrecytokine regulationstroke
Ginsenoside compound KPanax ginsengautophagy regulationAD
Ginsenoside Rb1Panax ginsengautophagy regulationspinal cord injury
HederageninHedera helixautophagy regulationPD
Huperzine AHuperzia serrataneurotransmitters and synaptic functionAD
IcariinEpimedium segittatumcytokine regulationAD, stroke, depression
Icariside IIEpimedium brevicornumcytokine regulationAD
IsobavachalconePsoralea corylifoliaPD
LuteolinLonicera japonicaautophagy regulationAD
Maslinic acidOlea europaeaoxygen-glucose deprivation-induced injury model
NeferineNelumbo nuciferaautophagy regulationHD
OleuropeinOlea europaeaautophagy regulationPD
PaeonolCortex Moutancytokine regulationPD
PiperinePiper longum L.autophagy regulationPD
Resveratrolred wineautophagy regulation, glucose metabolismAD, PD, HD, and healthy older adults
RuscogeninOphiopogon japonicascytokine regulationIschemic stroke
Sulforaphanecruciferous vegetablesautophagy regulationPD, HD
TetrandrineStephania tetrandracytokine regulationAD
Thamnolia vermicularis extractThamnolia vermicularisautophagy regulationAD
TriptolideTripterygium wilfordiiautophagy regulationAD, PD

Results also indicated that herbal extracts hold great potential for treating neurodegenerative diseases through targeting the modulation of autophagy:

 

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